Analysis of Genomic Characteristics of SARS-CoV-2 in Italy, 29 January to 27 March 20202020년 1월 29일부터 3월 27일까지 이탈리아에서 SARS-CoV-2의 게놈 특성 분석Article Published on 2022-02-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis authors B.1 center circulation collected Continuous dated phylogeny descendant epidemiological data Evolution Evolutionary rate gene flow gene flows Genome genomes Genomics genomics. highest HPD interval investigated Italian regions Italy lineage B.1 lineages majority molecular Next-generation sequencing NGS North O -glycosylation occurred performed Phylogenetic analysis Phylogeny reported SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 lineage South Spread suggested Surveillance virus [DOI] 10.3390/v14030472 PMC 바로가기 [Article Type] Article
Furin cleavage of the SARS-CoV-2 spike is modulated by O -glycosylationSARS-COV-2 스파이크의 푸린 절단은 O- 글리코 실화에 의해 조절된다.407 Published on 2021-11-032022-08-13 Journal: Proceedings of the National Academy of Sciences of [Category] Biochemistry, COVID-19, SARS, [키워드] O- abrogate Alpha alpha and delta variants Amino acid amino acids cells circumvent cleavage coronavirus decrease delta variant Delta variants dependent on expressed family members furin furin cleavage furin cleavage of S furin cleavage site GALNT GALNT enzyme global pandemic glycosylating S glycosylation highlight host O -glycosylation host-mediated O -glycosylation human respiratory cell human respiratory cells increase insertion insertion site modulated modulating Mutation O -glycosylation P681 P681 mutation P681 mutations position position 681 proline pseudoviral infectivity respiratory responsible resulting SARS-CoV-2 coronavirus SARS-COV-2 infection shown Significance spike Spike protein syncytia formation target targets the SARS-CoV-2 the spike protein tropism unique Viral viral infectivity viral infectivity/tropism [DOI] 10.1073/pnas.2109905118 PMC 바로가기 [Article Type] 407
O-Glycosylation Landscapes of SARS-CoV-2 Spike ProteinsChemistry Published on 2021-09-062022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] acute respiratory syndrome assigned binding mechanism characterized composed coronavirus digestion drugs EThcD EThcD fragmentation expected facilitate glycosylated glycosylation High-resolution host cell landscape mass spectrometry membrane fusion MOST O -glycosylation O-glycosylation peptide PNGase F Protein Proteins reported S protein S proteins S1 subunit SARS-CoV-2 SARS-CoV-2 S sequence spike Spike protein the S protein the SARS-CoV-2 trypsin Vaccine [DOI] 10.3389/fchem.2021.689521 PMC 바로가기 [Article Type] Chemistry
O -glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” ruleLetter to the Editor Published on 2021-08-022022-11-01 Journal: Cell Research [Category] COVID-19, MERS, SARS, [키워드] glycosylation O -glycosylation Proteomic analysis reveal Spike protein the SARS-CoV-2 [DOI] 10.1038/s41422-021-00545-2 PMC 바로가기 [Article Type] Letter to the Editor